Miranda E. Orr, PhD, is an Associate Professor of Neurology and co-director of the Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center at Washington University in St. Louis, MO. She also holds a joint appointment as a Research Health Scientist at the Department of Veterans Affairs.

With over 15 years of expertise in aging biology and neurodegenerative diseases, Dr. Orr is recognized for discovering a link between cellular senescence and tau pathology in Alzheimer’s disease, and for leading the first clinical trials of senolytics in Alzheimer's disease, including an on-going multi-site phase 2 trial funded by the Alzheimer’s Drug Discovery Foundation. Her translational research integrates spatial biology technologies to map mouse and human brain tissue across the lifespan, offering new insights into disease mechanisms and therapeutic targets.

Dr. Orr’s work is supported by the NIH, the Department of Veterans Affairs, and several foundations including the American Foundation for Aging Research and the Cure Alzheimer’s Fund. In addition to publishing her research findings in top-tier scientific journals, her work has been featured multiple times in National Geographic, demonstrating its impact both within the scientific community and the broader public. Prestigious accolades include the inaugural Jarrahi Geroscience Scholar Award and the Melvin R. Goodes Prize for Excellence in Drug Development.

Dr. Orr is also committed to multiple educational initiatives, including serving as co-investigator on the NIH-funded Geroscience Education and Training (GET) Network initiative, helping develop curricula for the next generation of geroscientists.